A Study On Some Virulence Factors And Its Relation To Drug Resistance Of Escherichia Coli Isolated From Urinary Tract Infection

Abstract

Urinary tract infection (UTI) is a bacterial infection which can happen anywhere along the urinary
tract, it is a common health problem in the world,
affecting both sexes with different ages. Effective therapy is based on antibiotics, but bacterial
resistance is an ongoing issue for management of
UTI, there is a serious health threats with respect
to drug resistance. This study aimed for focusing
the relation of drug resistance and some virulence
factors of the main UTI causative agent, Escherichia coli, which was conducted in Baghdad hospital. 160 mid stream urine samples were collected
from patients, and processed, to detect virulence
factors of UPEC strains isolated and to compare
the frequency of drug resistance pattern. The results revealed higher proportion of UTI in females
than in males. E. coli isolates were tested against
ten antibiotics. Their effect ranged from resistance
to intermediate susceptibility to full sensitivity.
The results showed that all E. coli strains were
highest rate of resistance with Amoxicillin, Amoxicillin/clavulanic acid and moderately resistant to
Cerfotaxim, CoTrimoxizole (Trmiethoprim-Sulfacmehaxazole), levofloxacin and Nadixic acid ,
where as some isolates had shown lowest rates of
resistance to Nitrofurantion, Ciprofloxacin, Norfloxacin and mipenem. E. coli showed multiple resistances to more than one antibiotic, a collective
result obtained showed that 17 (65.4%) strains
from a total of 26 E.coli isolated from urinary tract
infections, while isolates with low resistance is 9
(34.6%.).