1) Clinical Aspects and Patterns of Treatment Response to Steroid in Children with Idiopathic Nephrotic Syndrome in Mukalla Maternity and Child Hospital, Hadhramout, Yemen

Abstract

Background: Idiopathic nephrotic syndrome (INS) is a common and important chronic kidney disease in childhood.

Objectives:  The objective of this study was to illustrate the clinical aspects and treatment response pattern of the Idiopathic nephrotic syndrome steroid.

Methods: A six-year retrospective research was conducted on children with INS who were treated at Mukalla Maternity and Child Hospital in Hadhramout, Yemen.

Results: This study included 62 children aged 1-15. All patients were complained from generalized edema 100 (100%), followed by abdominal distension 44 (71%) and ascites 40 (64.5%). Children older than 6 years, and those presenting with hypertension or hematuria, were significantly more represented in the steroid-resistant group compared to the steroid-sensitive group (P < 0.05). Forty nine patients (79%) were steroid sensitive nephrotic syndrome, of whom seven children (14.3%) developed complete remission and 42 children (85.7%) developed relapsed of whom 19 children (38.8%) had infrequent relapses, 11 children (22.4%) had frequent relapsing, and 12 children (24.5%) had steroid depend. Thirteen patients (21%) were steroid resistant nephrotic syndrome.

Conclusions: A relapsing course was observed in most children with INS. The patients were really needed biopsy in order to give proper protocol for treatment and to the determine prognosis.